Houston Beat Oklahoma State 35-32 as Weigman Throws Five Touchdowns

Houston beat Oklahoma State 35 to 32 at TDECU Stadium in Houston on Saturday, October 17, 2026, in a game where the lead kept changing hands and neither quarterback would stop answering. Conner Weigman threw for 343 yards and five touchdowns for the Cougars. Drew Mestemaker threw for 365 yards and three touchdowns for the Cowboys, who scored 29 points in the second half and still lost.

Houston is 6 and 1 and 3 and 1 in the Big 12, and it stayed perfect at home. Oklahoma State falls to 4 and 2 and 2 and 1 in the Big 12, and its four game winning streak is over. The two teams combined for 1,004 yards of offense, 505 for Houston and 499 for Oklahoma State.

Houston leads at the break

Oklahoma State scored first. Lyrik Fields intercepted Weigman on the opening possession, the Cowboys drove inside the Houston 10, and Sam Keltner kicked a 23 yard field goal. Houston answered with a 75 yard drive that ended with a 2 yard touchdown pass from Weigman to Patrick Overmyer.

The Cowboys reached the Houston 2 early in the second quarter and came away with nothing, turning the ball over on downs. Houston then intercepted Mestemaker and took over at the Oklahoma State 25. Weigman found Amare Thomas for a 7 yard touchdown, and Houston led 14 to 3 at halftime.

The second half shootout

Oklahoma State opened the second half with a 75 yard touchdown drive, finished by a 13 yard run from Ayo Adeyi. Houston answered at once. Weigman hit Thomas for 51 yards to set up a 2 yard touchdown pass to Trent Walker, and the lead was back to 11.

Mestemaker drove the Cowboys 90 yards and threw a 2 yard touchdown pass to Wyatt Young. Houston answered again, on a 21 yard touchdown pass from Weigman to Thomas late in the third quarter, and led 28 to 17.

The fourth quarter kept the pattern. After a Mestemaker fumble ended one drive, he needed one play to score, a 66 yard touchdown pass to Caleb Hawkins. The two point conversion made it 28 to 25 with 11 minutes and 57 seconds left. Weigman replied with a 48 yard touchdown pass to Koby Young with 9 minutes and 48 seconds left. Mestemaker then led an 88 yard drive in 10 plays and found Justin Bowick for an 8 yard touchdown with 4 minutes and 54 seconds left, and the score was 35 to 32.

Houston keeps the ball

Oklahoma State never got the ball back. Houston held possession on the final drive, converted a third down on an 18 yard completion from Weigman to Walker, and ran out the clock and all three Oklahoma State timeouts.

Thomas caught seven passes for 126 yards and two touchdowns for Houston. Walker caught seven for 104 yards and a score, and Koby Young caught five for 99 yards and a touchdown. For Oklahoma State, Hawkins caught seven passes for 125 yards and a touchdown and ran for 68 yards on 17 carries. Mestemaker threw one interception and lost a fumble. Weigman threw one interception to go with his five touchdown passes.

What it means

Houston has a signature home win in the Big 12 race and a quarterback playing the best football of his career. Oklahoma State scored 29 points after halftime on the road and lost anyway, because its defense could not get one stop in the fourth quarter. The Cowboys return home for homecoming against Colorado next Saturday.